Here we report that transgenic expression of DVAP-V260I recapitulates major hallmarks of the human disease including aggregate formation, reduced viability, neuromuscular defects, abnormal locomotion behavior, neurodegeneration and upregulation of the heat-shock-mediated stress response.
"I can recapitulate that game in sequence," Majerus said of the championship meeting.
Cancer stem cells (CSCs) are defined by their ability to (i) fully recapitulate the tumor of origin when transplanted into immunodeficient mouse hosts, and (ii) self-renew, demonstrated by their ability to be serially transplanted.
The ideal mouse model for drug development would (i) faithfully recapitulate the genetics and molecular characteristics of the human tumor in question; (ii) posses a short tumor latency and high penetrance; (iii) be relatively simple to generate and easy to use; and (iv) ideally, would contain a built-in mechanism to assess therapeutic effects, such as a bioluminescent reporter (see below).
In discussing my career, I have recapitulated the major phases of cancer progression to illustrate how challenges have created opportunities for me.
In order to partially validate the statin implementation and test its ability to capture known effects of the drug on the modeled behaviors, we verified that simulations in the phase I population recapitulated the increase in PCSK9 reported clinically for statin treatment.
With a more than 2-fold increase in GUS activity after a 10 h treatment at 8°C the expression pattern of the original tagged line 17 under LT stress at cell colony stage I was recapitulated in the back-transformed lines carrying the full-length 17-1 promoter sequence.
I won't recapitulate the details of the controversy, which received immediate attention on The New York Times site (in both Economix and in Paul Krugman's column and blog) and in other news media, including The Washington Post, The Financial Times and National Public Radio.
To see why this is a problem, I will first recapitulate Williams' arguments for disregarding the mental domain in scientific discourse (Williams 1985).
The rationale for and operation of re-review opt-out are explained in the editorial [ 4] we published when we started the experiment, and I will not recapitulate them in detail here.
