Sentence examples for i markedly from inspiring English sources

I observed 44 m.p.g. over a careful 60-mile highway cruise and 40 m.p.g. when I markedly picked up the pace.

Results demonstrated a significant promotion of AGEs not only to RAGEs [ 49, 50], but also to the TGF- β1 and TGFR I markedly with a dose dependence.

However, applying the set of rules defined in phase I markedly improved the capacity of centers to detect the low to moderate T-cell responses.

Supporting these findings, in transfected HEK293 cells ANP, via GC-A/PKG I, markedly induced the expression of RGS2 and its translocation to the plasma membrane.

Thus, reduced blood glucose concentrations following acarbose treatment may result in (i) markedly lower stimulation of insulin synthesis and insulin secretion and (ii) decreased insulin resistance-induced hyperinsulinemia [ 22].

And the AGE-BSAs also promoted the receptors for AGEs (RAGEs) and receptor I for TGF- β (TGFR I) markedly with a dose dependence, whereas the Sirt 1 was significantly downregulated by the AGE-BSA at both mRNA and protein levels.

As quantified grossly and in cross-section (Figure 4 D, E), 10 mg/kg daily calpain inhibitor-I markedly reduced blind ends and increased vessel lumens similarly to DN calpain-I.

Similarly, in MVECs undergoing cord formation in response to stimulation with collagen I, both calpastatin peptide and DN calpain-I markedly increased actin cable length (Supporting Information Fig. S3C, D).

Notably, we found that expression of the RING domain deletion mutant REULΔRING (Aa 91 432), which was sufficient to bind to RIG-I, markedly suppressed RIG-I-, but not MDA5-mediated ISRE, NF-κB and IFN-β promoter in a dose-dependent manner (Fig. 3G, H, I).

Here, alkylation of His at the active site of PhTX-I markedly abolished enzymatic activity (<4% residual activity).

Additive effects were previously shown in highly ML-sensitive Jurkat cells, where very low nontoxic concentrations of purified ML-I markedly enhanced etopside-induced apoptosis [ 33].