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In the latter, HLA class I loss was preferentially associated with that of β2m, while in the former HLA class I loss was associated with that of one or more APM components (p < 0.0001).
HLA class I loss was seen more frequently in MSI-H tumors than in MSS tumors (p < 0.0001).
Indeed, immunohistochemical staining with mAb showed that HLA class I loss was frequent in the MSI-H canalyzedlyzed when compared to their MSS counterpart.
Partial HLA class I loss was observed to be significantly associated with decreased OS; correspondingly, reports in colon cancer have shown partial, but not total HLA class I loss to be associated with worse OS [ 49].
Partial HLA class I loss was significantly associated with decreased 5-years overall survival (61% vs. 83% for normal expression; P < 0.05) and was associated with decreased 5-years disease-free survival (DFS) (65% vs. 82% for normal expression; P = 0.05).
Similar(55)
HLA class I loss is a significant mechanism of immune evasion by cervical carcinoma, interfering with the development of immunotherapies and cancer vaccines.
Our results lead us to the following conclusions: (a) HLA class I losses were found in a group of tumours showing greater aggressiveness and worse prognosis; (b) these alterations in expression were not associated with an increased metastatic potential.
Average back exchange (i.e., deuterium loss) was measured as 37%.
Average back exchange (i.e., deuterium loss) was measured as 37% for the analyzed peptides.
"Since I know his loss is coming, I pray to God that it is total".
I think that the Illinois loss was an aberration.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com