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The primary target for CMVs will be modulation of antigen presentation in the endosomal system, either by retrieval of MHC I loaded with viral peptides into endosomal compartments or redirection of MHC I trafficking and disruption of endosomal peptide loading.
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The approach has since been extended to a general bimaterial interface geometry under mixed-mode I/II loading, with application to fatigue debonding of layered materials.
While efficient MHC Class I loading with exogenous antigen has been shown to occur in early endosomes (13), some endosome-to-lysosome trafficking or exchange of MHC Class I containing antigenic peptide, can not be excluded particularly at later time points (6 hr) that could be occurring during fusion of endocytic compartments while processing the exogenous antigen.
As I leave, loaded with pies, I thank the Lord I am not called Simon.
I loaded my backpack with a computer and GPS receivers.
I loaded her up with sanitary towels and silently hoped for the best.
I loaded them up with ice and we've got some food that we cooked up".
I loaded my plate with an American-size portion of fresh fruit, several entrees and a huge green salad.
I loaded my backpack with pharmaceuticals, got shots and took Larium, antimalarial pills.
I loaded my Rolly with tunes (it has a 1-gigabyte memory card) and told it to assign dance moves automatically.
I loaded my glass with some upstate weed and then offered Haroon the first hit.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com