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Addition and multiplication of signs can be understood as natural addition and multiplication of regulatory influences, that is, if two transcription factors inhibit a gene G i, then G i is down-regulated when both of them are active or expressed.
"I'm down.
I'm down fifty-nine bucks.
I'm down the block".
I'm down with Big Bird.
I was down there that morning.
Now I'm down to 50.
But now I'm down to $13".
"I'm down for that," Johnny Meatball said.
I am down on this Nigger stealing".
I'm down a contact lens.
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