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Cytokeratin 8 (CK8), together with its heterodimeric partners CK18 and CK19, has been demonstrated to inhibit MHC I interactions with TCRs on CD8+ CD8+73.
MHC class I interactions with Ly49 receptors have three measurable effects: Inhibition of NK cell activation, downmodulation of Ly49 expression levels, and education of NK cells to learn what is "self" MHC class I.
As summarized in Table I, interactions with PIPs have been reported for a large number of TRP channels.
(I ) Interactions with non-social stimuli (objects/plastinated rats) had lower calling rates and no touch-associated modulation (bin size: 500 ms).
Furthermore, recent reports about an association of BD with ERAP1 and KLRC4 implicated altered peptide-MHC class I interactions with natural killer (NK) cell receptors which could influence NK-cell activity in the pathogenesis of the disease [ 11].
PDIviz provides three principal visualization modes, which highlight (i) interactions with DNA bases and the sugar-phosphate backbone (buttons of the 1st column), (ii) interactions with the major and minor groove (2nd column) and (iii) interactions with atoms of different pharmacophoric type (3rd column).
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There are three major obstacles for delivery of RNA NPs: (i) Interaction with blood components.
In this way, UL18 could gain access to peptide ligands and simultaneously interrupt MHC I interaction with the PLC.
Tumor resistance to specific treatment could result from (i) interaction with the host [ 1] or (ii) genetic or epigenetic alterations of malignant cells [ 2].
AMPAR movement in the PSD is thought to be affected mainly by two factors: (i) interaction with scaffold molecules, and (ii) entrance/exit rates of receptors to/from the PSD.
The proportion of losses by i in interaction with j is P ji = 1 − P ij (Gammell, De Vries, Jennings, Carlin, & Hayden, 2003).
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