Here, we have drawn on a large database of known peptide-HLA-I interactions to develop a bioinformatics method, which takes both peptide and HLA sequence information into account, and generates quantitative predictions of the affinity of any peptide-HLA-I interaction.
In contrast, camptothecin exposure induces one-ended DSBs by stabilizing DNA-topo-I interactions to prevent re-ligation of topo I-induced SSBs, thus leading to replication fork collapse.
Endothelial cell adhesion to ECM, via integrins-collagen I interaction, leads to activation and/or suppression of multiple signalling pathways.
In addition, the p130Cas-CrkII interaction appears to be functionally important for Salmonella-induced cytoskeletal rearrangement.
Therefore, we tested all loci with a significant sex by i interaction effect to confirm that the effect was not caused by a sex-dependent maternal genetic effect [cf. [ 47]].
Although we noted that compared to GFP‐gephyrin, less GFP‐G375D‐expressing cells formed CBII‐induced submembranous microclusters (Fig EV2C), we conclude that this effect is not responsible for the severe cluster deficiency observed in neurons and gephyrin CBII interaction seemed to be intact in the mutant.
Because of prior studies showing that associations of sex steroid-related SNPs may be more evident among women with BMI greater than 25 [ 69], we conducted secondary analyses wherein we added an SNP*BMI interaction term to the multivariable linear regression models.
If this analysis is done in single MHC class I mice, a comprehensive picture of which Ly49/MHC class I interactions that lead to functional responsiveness would be obtained.
Type I interactions allow compaction to be tuned within a physiological range.
Class I interactions are confined to the seed region, whereas classes II and III additionally involve miRNA nucleotides 13 16 and 17 21, respectively.
We found that the effects of APS-IgG upon the FXa-AT-III interaction were related to binding to FXa rather than to AT-III because we did not find a correlation between the presence of anti-AT-III IgG and reduction of AT-III-mediated inhibition of FXa.
