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The fact that TG potently inhibits SERCA allows us to exploit this tool experimentally and account for these other sources of P i. P i generated from SERCA activity is defined by the difference in P i generated in one condition minus the P i generated in the same condition in the presence of TG.
By contrast, the centroids of clusters in the set A i generated in each of iterations of our algorithm in different runs are significantly similar to the selected discriminative genes in Δ ′ 1 and Δ ′ 2 at most iteration steps.
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Thereby, ApoA-I generated in the ER is transported to the Golgi separately from pre-chylomicron vesicles and is added within the Golgi to the chylomicron before the mature particle is secreted into the lymph [ 45, 62].
One explanation is that lipid free apoA-I, generated in vivo through an apoA-I remodeling cycle is rapidly lipidated by ABCA1, or may be incorporated in preexisting plasma HDL [135].
To determine whether this mechanism for activating latent myostatin functions in vivo, I generated mice in which the aspartate to alanine change in the propeptide was introduced into the germline.
It made my legs stronger, and I generated power in the legs".
"I hadn't played that many minutes at that high a tempo," Fedorov said of Game 2. "Tonight, I generated speed in the neutral zone.
"It's material that Eddie and I generated, literally, in 1975, 1976 and 1977," Roth said.
To determine whether FLRG can also inhibit myostatin activity in vivo, I generated a construct in which the FLRG coding sequence was placed downstream of a myosin light chain promoter/enhancer.
As shown in Figure 3a, I generated a construct in which a LoxP site and a LoxP/neo cassette were introduced into introns 6 and 7, respectively.
To accomplish these issues and explore the relationship between MCMs and disease, I generated mice deficient in MCMs as a model of in vivo disease in this thesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com