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The lack of class I evidences about most of the discussed issues is constraining and the need for further studies on medical and surgical effectiveness is undoubted.
Based on the level I evidences, meta-analyses showed that intravenous tranexamic acid appears effective and safe in reducing allogeneic blood transfusion and blood loss in TKA without increasing the risk of thromboembolic complications [ 28, 29].
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Level I evidence.
These trials provide level I evidence of the efficacy of these drugs.
Only one study met the criteria of class I "evidence for intervention" studies.
A weakness of this study is the lack of available level I evidence.
No level I evidence exists for low-grade gliomas.
Level I evidence was that contained in systematic reviews (SRs) of randomized controlled trials (RCTs).
Thus, no class I evidence may be extrapolated.
No study yielding 'level I' evidence (Table 1) was identified.
Of these, 21 (72.4%) were based on level I evidence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com