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The cumulative frequency distribution of reporting delays gives the probability of a case having been reported i days after the day of onset of symptoms, ρ i.
In the time-stratified approach, each month was a priori divided into two halves, (i) days 1 15 and (ii) days 16-end of month, and control day(s) were selected on the same weekday as the case within the same half of the month.
We set the current day as day 0. Our goal is to estimate the number of admissions i days ago, N i.
We are looking for the actual number of admissions i days ago, N i, given the number of reported cases for that day so far, C i. We note that the number of observed cases is the product of the reporting probability ρ i and the actual number of cases N i : C i = ρ i N i.
We then looked for the ' β-tubulin double band phenotype' on western blots of ICEU-treated tumours at several stages, that is, (i) days 9 and 11 that corresponded to a high tumour growth inhibition, (ii) day 15 to a moderate tumour growth inhibition and (iii) day 18 that corresponded to tumour relapse.
Subjects continued their Neoral regimen during period I (days 1-14).
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