The primary condition for reaching this high therapeutic efficacy is the perfect match between two molecular interfaces: (I) complementarity determining region of the anti-HER-2 antibody and the antibody docking domain of the HER-2 receptor; (II) the complementarity determining region of anti-HBsAg antibody and the antibody hosting domain of the HBsAg.
We employed three criteria for RSCA primer design: (i) complementarity to a conserved region, including all possible sequences in the detected MHC allele pool, (ii) amplification of most of the highly variable exon 2 (iii) binding of both primers within the exon 2 to avoid any length variation of the amplicon.
I regard complementarity of amino acid roles as imposing strong constraints on the establishment of the code.
The first one, i.e. Complementarity measure for time series prediction (ComTSP), is properly modified from Complementarity measure (COM) for classification.
DNA/RNA origami, a new programmed nucleic acid assembly system, uses the nature of nucleic acid complementarity (i.e., the specificity of Watson Crick base pairing) for the construction of nanostructures by means of the intermolecular interactions of DNA/RNA strands.
Considering template-copy sequence complementarity (i.e., the phenotype-genotype distinction) does not change this picture, at least not radically.
However, partial primer complementarity (i.e. complementarity of only 8 adenine nucleotides in the primer's sequence) is sufficient for the reaction initiation, and due to the random nature of the attachment it can also bind to the A-strands found commonly in the UTRs [ 71].
aPL = antiphospholipid antibodies; APS = antiphospholipid syndrome; β2GPI = beta2 glycoprotein I; CDR = complementarity determining region; CL = cardiolipin; dsDNA = double-stranded DNA; ELISA = enzyme-linked immunosorbent assay; Fab = antigen-binding fragment; VH = variable heavy chainregion; VL = variable light chainregion.
We predicted that mutants I369L, I369F, A370V, and A370L would lead to improved steric complementarity, i.e., Van der Waals interactions, between CYP3A4 and the 5 H-dibenzo[ b, f]azepine ring system of CBZ.
Factors other than seed region complementarity (i.e., expression of other miRNAs, differential expression of miRNA-induced silencing complex components, presence of other mRNA-binding factors, target mRNAs, target site-containing noncoding RNAs, etc).
To avoid conflating nonlinearities arising from increasing suppressive strength and from complementarities, I keep total suppressive strength fixed while varying the proportion given to non-disruptive tactics, for several levels of suppressive strength.
