I made an insertion of my own: as I read, the word "Ida" started to become a pronoun and a verb: I da won't, I da will, I da wanna.
There are three possible alignment states M, I t and I s, where M represents two residues being aligned, I t denotes an insertion in the template and I s denotes an insertion in the sequence.
i) A homozygous insertion is defined as sites with all flankers and no spanners.
Let D i, j and E i, j denote the optimal score of a subalignment ending in a deletion (x i, −) and an insertion (−, y j ), respectively, and M i, j denote the optimal score of a subalignment ending in a substitution (x i, y j ), i.e. a match or mismatch.
M represents two residues in alignment, I t denotes an insertion at the template protein, and I s denotes an insertion at the target protein.
If the non-reducing operation transforming u i -1 to u i is a mutation, an insertion, or a duplication of a letter within the prefix u i -1, a, then set u i, a to be the string obtained by applying this operation over u i -1, a, and set u i, b = u i -1, b.
In order to demonstrate that the authors are analyzing the desired homologously recombined allele and not an insertion (i.e., one arm homologous recombination), they should include a Southern of the -/- (i.e., FLOX/FLOX) mouse DNA.
The ACE gene consists of either an insertion (I) allele or a deletion (D) allele forming three possible genotypes: II, ID and DD [15].
In between two nodes, one can have an insertion (I) state.
The ACE gene is located at 17q23 and contains a polymorphism distinguished by either an insertion (I) or deletion (D) of a 287 base pair segment in intron 16.
