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ADH1C is the third gene of the class I alcohol dehydrogenase family consisting of ADH1A, ADH1B, and ADH1C.
The Class I alcohol dehydrogenase (ADH) is the major enzyme that catalyzes alcohol to acetaldehyde in liver.
The ADH1C gene encodes for class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family.
Familiarity with addiction was assessed by asking participants whether they, or someone they knew personally, had ever had a problem with i) alcohol or ii) heroin.
In humans, alcohol is almost entirely metabolised by oxidative detoxification, mainly dependent on two enzymes, class I alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH).
In this context, class I alcohol dehydrogenases (ADHs), which are important enzymes in the major pathway of alcohol metabolism in vivo and are expressed in normal mammary epithelium (Triano et al, 2003), may be relevant.
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