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This model measured the cumulative incidence among adherent, non-adherent, control and non-enrolled females in a hypothetical trial of HIV prevention.
Using a sensitivity analysis on data for a hypothetical trial, we compare these different analytical approaches in the context of two common protocol deviations: loss to follow-up and switching across treatments.
That is, what is the posterior or 'current probability' (not the probability in the long term of hypothetical trial repetitions) of observing this outcome in a given trial or population.
Consider a hypothetical trial that, based on power calculations, is scheduled to enroll 1000 patients.
We model the potential errors due to paired screening trial bias for this hypothetical trial.
Using the same MCID, we chose to simulate 500 participants in each hypothetical trial.
Similar(37)
We investigated the impact of the displacement of sexual activity from adherent recipients of an intervention to others within or outside a trial population on the results from hypothetical trials of different sexual behavior interventions.
In addition, the CIs generated from 95% of these hypothetical trials will cover the true mortality reduction.
Nineteen studies evaluated recruitment to hypothetical trials (table 1).
The retention trials were embedded in real trials (host trials) and not hypothetical trials.
Potential bias was also a problem in many of the studies, often linked to hypothetical trials.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com