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We demonstrated how expected changes in toxicity or efficacy profiles for a hypothetical comparator could be evaluated in terms of efficacy and cost metrics.
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For example, the hypothetical common comparator "C" can indirectly link comparators of interest "A" and "B" in Trial 1 comparing interventions "A" versus "C" and Trial 2 comparing "B" versus "C".
The novel device is considered in the analysis as a hypothetical scenario: a new comparator for which the effectiveness is varied between that of existing VCDs and a VCD with 100%% effectiveness, i.e. zero bleeding complications.
However, Trial 3 comparing "B" versus "D" would not be included in the hypothetical "A" versus "B" network since comparator "D" is neither a comparator of interest nor a common comparator that can indirectly inform an "A" versus "B" comparison.
The comparator was a hypothetical 'do nothing' scenario using generalized cost-effectiveness.
Teachers, parents and children will each complete a questionnaire at baseline, 6 and 16 weeks postintervention delivery start date (actual date if allocated to intervention and hypothetical date if allocated to comparator group, respectively).
Given that even a single pSIA targeting 0 5 year olds prevents the outbreak altogether in the model with all else equal, we constructed a hypothetical reference case scenario as a comparator for the pSIAs.
A study investigating the impact of a placebo group on women's willingness to participate in a hypothetical hormone replacement trial 59 suggests that the number likely to take part may be less when a non-active comparator is included (RR 0.76, 95% CI 0.59 to 0.99).
Hypothetical situations?
This hypothetical problem is not merely hypothetical.
Hypothetical women".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com