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Bounding calculations of thermal transients following a hypothetical (Category V) loss of coolant accident in two international thermonuclear experimental reactor (ITER) design options, EU-I and ITER-fusion energy advanced tokamak (FEAT), have been carried out for a variety of assumptions concerning heat-transfer to and heat rejection from, the cryostat.
However, transcription studies allow confirmation of the activity of hypothetical genes, pre-characterize and remove them from the hypothetical category [ 24, 25].
Within the 189 set, the relative distribution of antigens in 3 functional categories differs significantly from their distribution in the whole genome, with reduction in the Conserved hypothetical category (due to improved annotation) and enrichment in Lipid and in Virulence categories.
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Six of the localized proteins were annotated as hypothetical, a category that comprises 37% of the C. crescentus proteome [34].
When compared to their fraction in the whole genome [ 51], it appears that the Conserved hypothetical proteins category is under-represented in the list of 189 selected antigens, while the Lipid metabolism and Virulence, detoxification and adaptation categories are over-represented in the list of 189 selected antigens.
The map had 5 hypothetical risk categories.
Often this results in the categorization of many proteins into "unknown function" or "hypothetical protein" categories until experimentation provide light on the purpose of the gene at hand.
The JCVI role category "Hypothetical proteins" showed significant trends of having genes with low p-values in the Choleraesuis, Typhimurium and Paratyphi A branch specific tests for positive selection (Bonferroni corrected P = 0.042, P = 0.034 and P < 0.001, respectively; one sided U-test) as compared to genes in other role categories.
The majority of coordinately repressed genes in Cluster A belong to the functional category of hypothetical and conserved hypothetical proteins (Table 1).
The majority of these shared genes (71), were assigned to the General Function Prediction or Hypothetical Protein Prediction categories.
Interestingly, a majority of these motifs came from two categories, hypothetical proteins and proteins associated with phage-related functions, suggesting that further functional characterization will help better understand the epidemiological implications of such repeats in the genomics of X. fastidiosa strains.
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