We hypothesized that up-regulated genes were likely to be important in protecting C. elegans against mercurial toxicity.
Taking into account both sources of data, we hypothesized that up-regulated genes identified by microarray data and those genes that codify for the identified proteins potentially reveal those genes with a major role in nitrogen fixation.
Since PKC is required for 20E-induced gene expression and can block JH action [ 3, 6, 16], we hypothesized that up-regulation of calponin during the larval-pupal metamorphosis may facilitate 20E action by activating PKC.
Recently, several studies have indicated that SIRT1 expression was significantly reduced in diabetic heart [ 13, 14], we therefore hypothesized that up-regulation of cardiac SIRT1 in the diabetic condition may overcome the increased susceptibility of the diabetic heart to I/R injury.
This complexity of network structure makes it difficult to hypothesize up front what the regulatory dynamics might be and necessitates use of a model to explicate them.
In addition to detecting paroxysmal atrial fibrillation and initiating the necessary treatment, the following advantages of future use could be hypothesized: following up on the response to electroconversion and medical treatment, improving compliance with therapy and potentially decreasing medical costs (by means of the prevention of ischemic CVA).
Another mechanism hypothesized includes up-regulation of the p-glycoprotein efflux pump reducing intracellular PARP inhibitor concentrations [52].
Therefore, we hypothesized that up-regulation of PDGF-A is responsible for the failure of re-initiated IFN-α treatment against HCC.
As SIRT1 expression is considered to be reduced in diabetic heart, we therefore hypothesized that up-regulation of SIRT1 in the diabetic heart may overcome its increased susceptibility to ischemic injury.
Weakly interacting massive particle (WIMP), heavy, electromagnetically neutral subatomic particle that is hypothesized to make up most dark matter and therefore some 22 percent of the universe.
High-pressure H2O polymorphs, namely ice VI, ice VII, and ice X, are hypothesized to make up a considerable portion of the interiors of large icy satellites and select extra-solar planets.
