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Previously, we designed a series of ADK dimers as a new class of IN inhibitors that were hypothesized to target two divalent metal ions on the active site of IN.
sRNA28 is hypothesized to target stiB, a fimbrial chaperone gene, potentially allowing for sRNA28-based fine-tuning of Sti fimbriae expression [45].
In vertebrates, both natural and sexual selection have been hypothesized to target the immune system [ 21, 31].
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In particular, Nedd4 has been hypothesized to maintain target protein at the plasma membrane by balancing steady state insertion and retrieval of proteins critical to the development and neuronal function in the brain [ 57].
In a similar manner, genes that required ATM activity to establish the correct direction and timing of expression or were specifically regulated in atm (Fig.7 right side) were hypothesized to include targets regulated by other posttranslational regulators acting more upstream or downstream of ATM/ATR and/or further away from DSB sites, such as Tip60 and ARP4.
CBP is also required for LTM [25], and has been hypothesized to be a target gene for Notch signaling [13].
In the case of C7 H2, an N-terminal sequence in ALS3 is hypothesized to be a target based on its functional similarity with a peptide deduced by hydropathic complementarity to C7 H2 with codons read in the 3'–5' direction [37].
In that study COX-2 (cyclooxygenase-2) is hypothesized to be the target of DLGG action.
HLS1 is a well-known signal integrator of ethylene, light, auxin, sugar, and brassinolide (de Grauwe et al., 2005; Hou et al., 1993; Li et al., 2004; Ohto et al., 2006) and was previously hypothesized to be a target of ERF1 because of the presence of a GCC box motif in the HLS1 promoter region sequence (Lehman et al., 1996).
In this light, skeletal muscle cells, behaving as immunoactive structures, could be also hypothesized to be therapeutic targets as well.
This variable region has been hypothesized to be responsible for targeting different host proteins [ 46].
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