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HSP90, RAR1 and SGT1 are hypothesized to form a chaperone complex that mediates the folding of R-proteins and their incorporation into functional complexes.
The latter is a polytopic integral membrane protein, hypothesized to form a hydrophilic channel across the inner membrane for passage of DNA.
The position of the posterior dorsal fin and the anal fin are dissociated in many fishes, but have been hypothesized to form a developmental module together with the anus [ 26].
In some sequences, immediately C-terminal to the histidine at the end of the EFAGSF motif, are up to four additional histidines residues that have been hypothesized to form a third copper-binding domain [ 44].
These universal systems are hypothesized to form a biological foundation on which the cultural and individual variants of sexual, romantic, and longer term love are built (Gottschall and Nordlund 2006; Jankowiak and Fischer 1992).
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The acidic N-terminal extension is hypothesized to form an heterodimeric coiled-coil structure with the basic region, essentially zippering the leucine zipper into the basic region.
Are there other arguments for homology than just the conservation of a few functional residues that are hypothesized to form an intramembrane active site?
As one of the most potent inflammatory mediators and a major structural component of Gram-negative bacteria, LPS has been hypothesized to form an important risk factor of intestinal bowel disease (IBD) [ 45].
For example, residue N748 recognizes G-11 in the non-template strand via both direct and indirect hydrogen bonds; the N748D substitution has previously been hypothesized to form an alternate hydrogen-bonding network with the G-11C substitution [ 2].
The 53 or 59 amino acid cleaved peptides contain six of the seven cysteines found in Ara h 1 isoforms [ 40] and three of the allergenic epitopes [ 41], and are hypothesized to form disulfide bridges conferring a stable conformation similar to plant antifungal peptides [ 40].
The ubiquitous poly-A stretches are hypothesized to form hydrophobic crystalline domains that are responsible for the high tensile strength of the fiber [20] [24].
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