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The persistent efforts for malaria elimination in Moheli can be hypothesized to create a Mayotte-like setting requiring efficient vector control to prevent epidemics in a Mohelian population that is losing its immunity.
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The T-to-C substitution was initially hypothesized to create an Sp-1 binding site, which could lead to up-regulation of transcriptional activation of the variant allele and higher activity of the enzyme [ 8, 9], but this was not observed in experimental studies [ 10- 12].
The purpose of an open chromatin state is hypothesized to create the plasticity for mounting a rapid response to differentiation signals (reviewed in 47).
Neurons that are proximal to plaques display aberrant dystrophic neurites with disrupted trajectories indicative of synaptic dysfunction (for example, [ 88]) and plaques have been hypothesized to create and sustain neurotoxic microenvironments [ 89] and perturb mitochondrial function [ 90].
We hypothesize that Sir2 may act to create a nucleosomal environment that is permissive to Clr4 binding and activity.
It is hypothesized that these factors may combine to create a biological disposition that fosters the maintenance of an elevated body weight and works to restore the highest sustained body weight, thus precluding the long-term success of behavioral weight loss.
We used soil heating to create a disturbance gradient, and hypothesized that increased disturbance would facilitate invasion, which was confirmed by the experiments.
We hypothesized that tap-1 contains a recombination site to create a diverse Tap-1 family.
We therefore hypothesize that the maintenance of low-grade inflammation may serve to create a state of persistent insulin resistance to limit the amount of obesity.
Psychologist Erik Erikson hypothesized that a late stage of personal development is generativity: the need to create a positive legacy that lives on after death -- to leave a part of the self to future generations to help guide their lives.
We hypothesize that GAGs may be altered in IPF and that this contribute to create a pro-fibrotic environment.
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