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These genes have been referred to as housekeeping genes (HKGs) and are hypothesized to constitute a small set of genes required to maintain minimum basic cellular function [ 1].
Based on this evidence, these disorders have been hypothesized to constitute a testicular dysgenesis syndrome (TDS), which results from abnormal development of the testis and consequent malfunction of the Leydig cells (LC) and/or Sertoli cells (SC) during male sexual differentiation (Sharpe and Skakkebaek 2003; Skakkebaek et al. 2001).
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Reducing maladaptive cognitions is hypothesized to constitute an active therapeutic process in multidisciplinary pain programs featuring cognitive behavioral interventions.
Molecular data represent a useful resource in this context because they provide an assessment of effective genetic exchange between groups of individuals that are hypothesized to constitute an evolving biological entity [ 62].
Such studies frequently utilize mutagenesis to alter amino acid sequences hypothesized to constitute subcellular localization signals.
MiniCLEANis a single-phase noble liquid scintillator experiment designed to detect nuclear recoils due to weakly interacting massive particles hypothesized to constitute the dark matter.
Involved brain areas include the posterior cingulate cortex, the precuneus, the medial prefrontal cortex, mid-dorsolateral prefrontal and anterior temporal cortices and have been hypothesized to constitute the so-called "default mode network" (DMN) [5].
An interesting aspect of the partially causal network is the web of highly connected genes (colored yellow in the lower right corner of Figure 3), which we hypothesize to constitute some form of a functional module.
We hypothesized that PKMζ forms a bistable switch because it appears to constitute a positive feedback loop (PKMζ induces its local synthesis) part of which is ultrasensitive (PKMζ stimulates its synthesis through dual pathways).
However, the GlcNAc containing glycoprotein decoration LacDiNAc, found on gastric mucins and hypothesized to negatively impact H. pylori adhesion to the gastric mucosa (Kenny et al. 2012), was recently found to constitute a substrate for CHIT1 hydrolysis at turnover rates comparable with those of the native substrate (Larsen et al. 2014).
ISRs had been hypothesized earlier to constitute the then-unknown botryococcene synthase [ 68], but the recent in vitro studies from the Chappell laboratory, as described above, conclusively showed that these proteins are not necessary for botryococcene biosynthesis [ 34].
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