Chromosome breakage as a result of replication stress has been hypothesized to be the direct consequence of defective replication fork progression, or "collapsed" replication forks.
Because Przewalski's horses are the only truly wild horses existing today, they have been hypothesized to be the direct ancestors of domestic horses (Mohr 1959; Ryder 1994, fig. 1 B ).
Car ownership and home ownership, amongst other measures of household assets, have been hypothesized to be more direct indicators of material circumstances within the SEP construct (Davey-Smith and Egger, 1992).
Since proper actin filament assembly has been hypothesized to be a prerequisite for directed cellular motility [35], and implicated in Ang II-induced migration of other cell types [36], [37], we treated C2C12 myoblasts with a concentration gradient of Ang II and assessed the number of cells displaying altered cytoskeletal characteristics.
Previously, the pathogenesis of cidofovir-associated uveitis was hypothesized to be due to a direct reaction with the CMV; however, uveitis has been associated with the use of cidofovir in non-CMV-related viral infections as well [16].
Clinical features, such as chorea, transverse myelitis, cardiac valvular lesions, and accelerated atherosclerosis, are hypothesized to be due to a direct tissue-antibody interaction and cannot be explained purely by thrombosis.
Resulting tris-cup cis- and tris-chair trans-conformers were hypothesized to be capable of reducing direct packing contact of light-harvesting fluorene moieties from each other that should reduce the aggregation-related self-quenching effect derived from the π π stacking packing arrangement.
Furthermore, preclinical studies are useful for validating surrogate markers that are hypothesized to be either indirect or direct targets of the investigational agent.
MITF induction is hypothesized to be driven by the direct transcriptional action of HSF1 (either at the promoter level or at an intron-located regulatory site) or by the posttranslational stabilization of MITF via HSP70, which is strongly induced by 17-AAG.
Because introns flanked by direct repeats have been hypothesized to be preferentially deleted via genomic deletions [ 47], it is expected that throughout evolution, introns flanked by direct repeats will be preferentially lost.
