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A very important application is in nuclear reactors technology, where it governs the cooling of overheated fuel elements during hypothesized loss of coolant accidents (LOCAs).
It is as well possible that, apart from interacting with CypD, a functional J-domain carrying out proper import activity is essential for mounting a chemosensitive response, as previous studies have hypothesized loss of import motor activity in the development of oncocytic tumors.
As hypothesized, loss of the senescent population in p53 knockdown cells allowed the transformed population to increase as seen by the increase cells with the transformed morphology, the increase number of cells forming colonies and loosing the contact inhibition, and the increase ability to form clones in soft agar.
This model contradicts the hypothesized loss of function of mbtA (based on genome sequencing) described by Li et al. However, it is important to note that the consequences of the EntE truncation in mbtA have not been validated by functional studies, including those replacing the mbtA gene with a completed version.
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The Chrna7 results are explained by hypothesizing loss of an essential neuronal transcriptional enhancer required for ~80% of allelic Chrna7 promoter activity, while the Chrna7 promoter is upregulated in B lymphocytes by the transgene immunoglobulin enhancer.
Therefore, we hypothesized that loss of Splunc1 expression might result in persistent loss of Eustachian tube patency in Splunc1 −/− mice.
We hypothesized that loss of a core family member would have a stronger effect than loss of a parent or a sibling [ 29].
We hypothesized that loss of robust circadian rhythmicity in Kcnma1−/− mice was generated at the level of the SCN.
Therefore, it could be hypothesized that loss of transgene expression is caused by selective growth or survival of subclones with low expression levels of the transgene.
We thus hypothesized that loss of CD10 expression, a MEC surface peptidase, would signify basement membrane disruption and confer increased risk of relapse in DCIS.
Thus, we hypothesized that loss of HDAC6 may have an impact on dysregulated intracellular transport.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com