Enlargement of the aortic root has also been shown to be associated with arterial blood pressure in some studies [ 4- 8] but not others [ 9] leading some investigators to hypothesize its role in the development of hypertension [ 10, 11].
The positive modulation of a germin protein reported in this proteomic study was justified hypothesizing its role in producing hydrogen peroxide for apoplastic Fe reduction or in other stress response on the basis of sequence similarity to a Nicotiana attenuata germin protein [ 15, 58].
We hypothesized its possible role as a marker of more aggressive tumoural phenotype since it plays an important role in the DNA repair pathway and its expression could increase following DNA damage or accumulation of several genetic changes [ 11].
As noted, the evidence is stronger for the role of VLPFC in DPD, due, we hypothesized, to its role in emotional control.
Because MMP-2 is secreted by fibroblasts, produced mainly during the proliferative phase, we hypothesize that its role is less relevant in chronic wounds, where the inflammatory phase predominates.
Moreover, progesterone regulation of these gene sets may underlie its hypothesized role as a promoter of malignant lesions in the breast [ 13- 15].
This creates a mechanism of haptic feedback whereby the cells "pull" on each other with the stress fiber acting as a mechanosensor during collisions, similar to its hypothesized role in sensing substrate stiffness (Trichet et al., 2012).
It is not known why melanocytes maintain higher levels of ROS than other cell types, but we hypothesized a role for melanin since its presence is a distinguishing feature of melanocytes and melanin synthesis is known to generate ROS [ 5].
Lu et al. [ 33] hypothesized a role for small-85 in loss of SRK function in A. thaliana with its accumulation.
The role of Grem2 in zebrafish atrial development, as well as the association between human GREM2-Q76E AFd AF, led us to hypothesize that, in addition to its role in cardiac morphogenesis, GREM2 is an upstream regulatory factor of the genetic network controlling cardiac rhythm.
