We hypothesize that danger signals (dead neurons and amyloid-ß peptides) alter functional phenotype of innate immune cells from the homeostatic (M0) to newly discovered neurodegenerative (MGnD) phenotype.
Role Description: We hypothesize that danger signals (dead neurons, dystrophic axons and amyloid-ß peptides) induce APOE signaling, which alters functional phenotype of microglia from the homeostatic (M0) to neurodegenerative MGnD) phenotype in a gender-dependent manner.
Coupling the aforementioned observations with the presence of introns at the C-terminus of microdomain I sequences (Figure 2B), we hypothesize that DANGER sequences have acquired microdomain I through exon-shuffling [17] early in vertebrate evolution.
Several clues converge to hypothesize that peripheral danger presentation can trigger off a fast arousal network potentially independent of the consciousness spot.
Furthermore, based on our previous studies, [12, 30] it was hypothesized that FPS to the danger cue (CS+) and impaired inhibition of FPS in the presence of the safety cue (CS−) would be associated with PTSD symptom severity.
Metallothionein has been shown to mediate leukocyte chemotaxis and has been hypothesized to serve as an early "danger signal" during times of stress or infection to activate an immune response [ 62].
Because uric acid has been found to be a danger signal [ 6], we hypothesized that MSU could alert OBs through an autophagic response based on these data showing that the TOR pathway was downregulated and that MSU-activated OBs reduced their proliferation without alteration of their viability.
We hypothesized that the carotid body, a tissue of neural crest origin, detect pathogen associated molecular patterns and danger associated molecular patterns via an inflammasome-dependent mechanism similar to that described in immune cells.
It was hypothesized that this killing process allows tumor immunity to be stimulated via the release of various molecules that serve as "danger signals".
He hypothesized about possible suspects.
So, scientists hypothesized, AIDS originated there.
