The goals of Phase II trials are to provide either a proof of mechanism or a proof of the hypothesized therapeutic concept, identify the patient population in which the new drug appears to work, and determine an appropriate dose regimen for subsequent large-scale trials.
British natural philosopher Richard Laming first hypothesized the concept of an indivisible quantity of electric charge to explain the chemical properties of atoms in 1838; Irish physicist George Johnstone Stoney named this charge 'electron' in 1891, and J. J. Thomson and his team of British physicists identified it as a particle in 1897.
However, because our experiments represent an initial investigation, we constructed stimuli with very short-tenure newcomers (4 9 days) to maximize the probability that they would activate the hypothesized newcomer concept.
Contextual concepts were hypothesized as unit-level concepts (i.e., scores on these variables were believed to be similar among nurses in a unit).
We would hypothesize that concepts that require spatial thinking, but lack direct perceptual character, may most effectively be taught via visualization technology aligned to embodied actions and yield greater gains for learners compared against traditional instruction.
We hypothesize that concepts of meaning construction, resource activation and the utilization of the clients' expectations help to explain the data.
Test of item discriminant validity focus on the integrity of hypothesized item groupings relative to the health concepts hypothesized.
Item-discriminant validity was determined to verify if each item correlated more strongly with the concept it was hypothesized to represent than with different concepts.
External variables may include measures, which the concept is expected to predict, as well as other scales hypothesized to measure the same concept, and related or different concepts.
Given the critical role of PP2A in the control of apoptotic events and in consistence with the rational of our DPT concept, we hypothesized that DPT-Vpr1 could contain a naturally occurring pro-apoptotic DPT-sequence.
