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The apoptotic pathways have been hypothesized as important in progression of esophageal squamous cell carcinoma (ESCC).
Correlated genetic responses have been hypothesized as important components of fishery-induced evolution, although predictive data from wild populations have been difficult to obtain.
The glutathione S-transferase (GST) metabolic pathway has been hypothesized as important to mode-of-action considerations (Caldwell and Keshava 2006), and GST polymorphisms are reported to influence RCC risk associated with TCE exposure (Brüning et al. 1997).
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Because this effect relates to fuel oxidation, dietary manipulation has been hypothesized as an important strategy during cancer treatment.
Given its unique geographic position, Northeast India is the only region which currently forms a land bridge between the Indian subcontinent and Southeast Asia, hence hypothesized as an important passage for the initial peopling of East Asia.
Oak related strains have been demonstrated to be freeze-thaw resistant which have been hypothesized as an important advantage to survive to winter niche [ 25].
Increased cardiomyocyte apoptosis has been described in hearts of diabetic mice and patients, and hypothesized as an important mechanism of DCM [ 28].
Decreased capillary density has been described in hearts of diabetic mice and patients, and hypothesized as an important mechanism of DCM [ 3, 12, 13].
Whether the patients would continue seeing the same specialist and the same referring physician for medical care was hypothesized as an important criterion for the patient's satisfaction with the patient centered information from the two physicians.
In the case of ARTIMMUS, however, an ABM approach was warranted due to the heterogeneity of cell populations, the need to account for phenomena occurring on distinct time scales, and features in the cellular environments hypothesized as being important contributors to EAE.
The sex of the child has been hypothesized as a potentially important risk factor in certain less developed parts of the world where there may be social and cultural pressures on women to give birth to sons [ 23].
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