Indeed, a vicious circle can be hypothesized in which oxidized SOD1 has an increased propensity to misfold, causing seeding and aggregation of SOD1 and resulting in a reduction of dismutase activity, which therefore feeds more potential oxidative stress to the start of the loop (Fig. 2).
The model presented in Figure 4 is one hypothesized manner in which CLI186 may act to integrate L and C signaling interactions that best accounts for and fits our analysis and interpretation of the microarray analyses carried out for cli186.
Structural Equation Modelling analysis technique was used to test a hypothesized model in which high RAM would positively affect Good Study Strategy (GSS) and study effort, which in turn would positively affect academic performance in the form of grade point averages.
Given the absence of lengthening of the cell cycle in dcr-2 embryos at uniform high temperature, we hypothesize a model in which the endo-siRNA pathway generates endo-siRNAs that act upon regulators of the cell cycle (Figure S7).
Given the morphological progression of the abnormal deposition with time, it is tempting to hypothesize a scenario, in which the first type of aggregates (Fig. 8A, D, G, J) could have been the developmental ancestor of the second (Fig. 8B, E, H, K) and in which each may illustrate different stages of pathogenesis.
We hypothesize that NSCLC in which CAIX is expressed present a more aggressive phenotype.
Klobuchar even echoed the Chamber's talking points about FCPA investigations "wreaking havoc" on businesses, and she gravely hypothesized a scenario in which giving a Chinese nurse cab fare back from a medical seminar would spark "a major investigation".
To explain this evolutionary trend, Fernández [ 36] hypothesized a model in which an attachment of new links between similar-degree nodes is disfavored.
Finally, we assumed that family dynamics will be adversely affected if caregiving continues for a long time, and thus we hypothesized that families in which caregiving had lasted longer would have higher IF-Long scores.
The authors hypothesized a timeline in which exposure to arsenic was followed by Bowen's disease within 10 years, invasive skin cancers after 20 years, and pulmonary cancers after 30 years.
