To test this hypothesis, we triggered osmotic damage of endosomes in cells expressing GFP-CLEC12A.
This hypothesis has triggered hundreds of research studies, and has improved understanding of illness processes in cardiovascular disease.
Consistent with this hypothesis, BPA triggered the activation of pro-caspase-9, as evidenced by a significant increase in the expression of cleaved (active) caspase-9 in INS-1 cells.
Defense responses governed by the gene-for-gene hypothesis are triggered in plants when the product of a plant resistance (R) gene directly or indirectly recognizes a specific pathogen effector molecule, which is often the product of a pathogen avirulence (avr) gene [ 1].
This study evaluates the hypothesis that triggering and eliminating induced static pelvic asymmetry (SPA) may be followed by immediate change in functional asymmetry of the lumbo-pelvo-hip complex.
Here, we tested the hypothesis that triggering germination could provide a novel strategy to enhance UV-C-induced UV-C-induced UV-C-inducedpores on surfaces, thereby reducing the time and radiation dose necessary for disinfection of hospital rooms with the UV-C device.
While epratuzumab appears to have only a very limited capacity to induce direct apoptosis [ 13, 14] via CDC and ADCC, the apparent reduction of peripheral blood CD27negative B-cells under therapy led to the hypothesis that triggering CD22 could modulate B-cell migration possibly resulting in reduced CD27negative B-cell counts in the blood.
Nevertheless, growing acceptance of the 'intestinal hypothesis' was mainly triggered by indirect rather than concrete scientific evidence.
That finding is consistent with Darwin's theory that eyes evolved once, and lends some support to Parker's hypothesis that vision triggered the Cambrian explosion of life forms.
Our findings suggest the hypothesis that autoimmunity triggered by TAAs may inflict epithelial damage to the breast, promoting chronic inflammation and cancer progression; i.e., that BC may behave as an organ-specific AD triggered by multiple epithelial and other breast antigens.
