12 Our analysis is based on a hypothesis that continues to evolve and has some limitations.
Recalling Feinberg's hypothesis, the disease appeared to evolve through changes in methylation.
This conflicts with the hypothesis that lower recombination tends to evolve among co-expressed genes [ 24, 41].
According to the cryptic female choice (CFC) hypothesis, male genitalia are thought to evolve to increase the male's chances of being chosen by females.
Comparisons of accessory gland proteins within and between fruit fly species have suggested that they often evolve rapidly due to natural selection [ 9], which is consistent with the hypothesis that these proteins tend to evolve due to sustained, antagonistic coevolution.
When constructing the LRTs, the null hypothesis fixes ω2 = 1, allowing sites evolving under negative selection in the background lineages to be released from constraint and to evolve neutrally on the foreground lineage; the alternative hypothesis constrains ω2 ≥ 1 [ 64].
Darwin's theory of evolution cites plenty of scientific evidence to support the hypothesis that species evolve to fit their environments.
And finally there is life itself, which according to the Gaia hypothesis, evolves to maintain optimum conditions for life.
Model-based phylogenetic inference has become one of the principal methods of using genetic sequence data to test scientific hypotheses pertaining to evolving populations.
Finally, Bartha (2012) models one's probability assignments to various theistic hypotheses as evolving over time according to a 'deliberational dynamics' somewhat analogous to the dynamics of evolution by natural selection.
On the basis of early studies suggesting that normal age-dependent increases in cellular Ca2+ are exacerbated in AD, the Ca2+ hypothesis has evolved to include multiple factors that might perturb Ca2+ homeostasis within the brain (Peterson et al., 1985; Gibson and Peterson, 1987; Toescu et al., 2004).
