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We set 3-D grids beneath the initial hypocenter, which may be a natural hypothesis to consider the upward migration of geofluids.
We wished, however, to expand the hypothesis to consider whether demographic traits followed two different trends, shifting in slope after the drought.
There is an alternative hypothesis to consider which would actually make the decision strategically quite smart.
Epigenetic inactivation of this gene would be a plausible alternate hypothesis to consider in the absence of genetic variation.
There is another interesting hypothesis to consider as well.
The other hypothesis to consider is that IgAN progression might not follow common pathways leading to ESRF.
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While the cost of randomization testing of each hypothesis stays the same, reducing the number of hypotheses to consider reduces the overall computational cost significantly.
One of the major hypotheses to consider is the proapoptotic effect of PKR activation, through triggering of a downstream caspase cascade.
Therefore, it is reasonable to propose that there are limitations to the CDCV hypothesis, and to consider the alternative common disease-rare variants (CDRV) hypothesis as a complement [5], [6], [7], [8].
Consistent with these considerations, the need of persistent OS1-179 expression to get Emx2 activation and the capability of the only drug cocktail to elicit weak but reproducible Emx2 upregulation induce us to rule out the latter hypothesis and to consider the former more likely.
The best way to describe this hypothesis is to consider evolutionary process as climbing of peaks on the fitness landscape.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com