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The thrifty gene hypothesis surrounding fetal growth aberration has been proposed as an explanation for increased insulin resistance in Indians (3).
Although the hypothesis surrounding the prevalence of these three disorders in association with IBS has been previously explored, many published studies have been based on data from clusters of case reports or from small clinical practices.
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According to the hemichannel hypothesis, surround illumination causes the horizontal cell to hyperpolarize, thus leading to an increase in the current flowing through both the hemichannels and the glutamate-gated channels [7], [9].
One hypothesis surrounds the relationship between TNFα and type 1 interferon (IFN) α, which is a key player in the pathogenesis of psoriasis.
Hypotheses surrounding the "second hit" that is necessary for the clinical presentation of the disease focus on maternal inflammation and oxidative stress.
One of the many hypotheses surrounding the improved outcomes in the use of beta blockade and noradrenergic sparing agents (i.e. vasopressin) in severe sepsis is that lowering the heart rate may improve diastolic function [23 25].
Whereas this apparent conundrum has been debated theoretically for many years, in this chapter we review prior hypotheses surrounding natural selection and neuropsychiatric disease and revisit them in light of the empirical genetic architecture that has only begun to emerge clearly in the past few years.
However, QTL mapping strategies could easily accommodate testing hypotheses surrounding sex-dependent penetrance or sex × gene interaction effects, as described below.
What is scientifically as exciting is that hypotheses surrounding more complex segregation models for the basis of genetic disease may now become testable.
Similarities in larval form initially provided the basis for many of the hypotheses surrounding the evolutionary origins of the chordates and, in particular, the centralized nervous system.
The aims of this paper are firstly to test the current phylogenetic hypotheses surrounding the higher level relationships among rodent families.
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