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Our experiments directly test this hypothesis, supporting its validity and, furthermore, pinpointing some physiological processes that may be targeted by the virus as it improves its fitness.
The hypothesis supporting this work is that pancreatic tumor progression and metastasis occurs only when circulating cancer cells can successfully resist the stresses generated by the new microenvironment provided by the host tissue.
Results for a similar analysis of downregulated pathways were: 89 total pathways (clusters): 6 (∼7%) significant; 10 hypothesis-related (associated with neuronal or myelin-related function, ∼11%); probability that 5 significant and hypothesis supporting pathways would be found by chance was highly unlikely (p = 7-5, binomial test).
Our findings agree with the brain reserve hypothesis supporting compensation for a fundamental underlying process which is associated with mortality.
One key hypothesis supporting this process is increased transcriptional activity of Ppargc1α (Pgc-1α) which is supported by 6 state changes.
This failure is related to spatial separation among populations of the two sexes and absence of male plants (or failure to express sex among male plants—'shy male hypothesis'), supporting previous suggestions by Gemmell (1950), Longton and Schuster (1983), Bowker et al. (2000), Oliveira and Pôrto (2002), Bisang and Hedenäs (2005), Stark et al. (2005).
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Is this hypothesis supported by the data?
This hypothesis supported by the results obtained from numerical simulations.
In our study, we had a hypothesis supported by theory and previous reports in septic patients.
But I believe the Hygiene Hypothesis supports a more likely cause for autoimmune conditions.
Thus, this hypothesis supported our findings.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com