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Consistent with our hypothesis, reduction of APP expression significantly affected cell proliferation and viability.
5. Modified two-hit hypothesis: reduction to homozygosity of low penetrance germline predisposition alleles.
The conditional power would have increased to 21.5% if the further data had followed the initial hypothesis (reduction of 30% of the prevalence of unprotected intercourse abroad).
5. Modified two-hit hypothesis: reduction to homozygosity of predisposition alleles Modified two-hit hypothesis: reduction to homozygosity of predisposition alleles In familial cancer predisposition syndromes, it is common for the remaining wild-type allele to be lost by LOH, for example BRCA1 pathogenic variants are usually reduced to homozygosity in breast and ovarian carcinomas [ 3, 27].
According to the current hypothesis, reduction of MDM4 could lead to more unbound p53 [ 53], but since this reduction also happened with Methotrexate only, it would not contribute to the observed synergy.
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All of the hypothesis' reductions of observable primary qualities, of secondary qualities, and of tertiary qualities, would inherit impulse's obscurity; thus Locke appears to be suggesting here that the corpuscular hypothesis cannot fulfill its promise of explaining and reducing those properties and powers.
Horowitz and Klein [14] support the hypothesis that reduction of fat oxidation during high-intensity exercise is caused by increased trapping of fatty acids within adipose tissue due to a decrease in blood flow and insufficient removal by the bloodstream.
This is also called the degeneracy hypothesis, or reduction hypothesis.
Consistent with this hypothesis, a reduction in the dose of the stat92E gene affects both cell cycle phasing and cell size in ept/M 3) tumors (see accompanying paper by Gilbert et al).
These results, together with the finding that NAS activity was not detectable in the β-globin hybrid constructs either (Figure 4C, right panel), support the hypothesis that reduction of dystrophin mRNA observed in vivo is probably due to NMD.
The hypothesis that reduction in trachoma follicular (TF) was related to environmental improvement in absence of antibiotic treatment is indeed supported by the readily availability of water and not the antibiotic.
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