However, if acupuncture is a causal intervention, investigators should be able to suggest a biological pathway, hypothesis or rationale for how it might work.
Typically subgroup analyses require specification of the subgroup hypothesis and rationale, and performed through inclusion of an interaction term (i.e. of the subgroup variable x main exposure variable) in the regression model.
Without placing undue burden on the applicant, descriptions of specific research hypotheses and rationale for why the requested data set is suitable along with analytic plan, might be informative.
Teams presented specific hypotheses and rationale with supporting literature, described their methods, explained their expected and alternative results in graphical form, and described potential implications of their research.
We believe that the rich process of inquiry, development of testable questions, refining of hypotheses, discussion of biological rationale for hypotheses, and use of data as evidence made these aha moments possible.
The Easson Stedman hypothesis provided the rationale for the first studies of drug design for the α1-adrenergic receptor.
This hypothesis provides the rationale for inhibition of bone resorption as therapeutic interference with growth progression in osteolytic bone metastasis.
We based this hypothesis on the rationale that LTNPs and/or patients with limited amounts of time with low CD4 counts would better retain key immunological features, such as lymphoid architecture and T cell homeostasis, and this in turn would allow their CD4+ T cell counts to recover more rapidly.
In any case, in this and previous studies educational level was not found to affect euthanasia prevalence unequivocally [ 18, 19, 32, 33]; the hypothesis and underlying rationale are not conclusively confirmed here.
One rationale hypothesis to explain the sensitising apoptotic effect of the molecule in rTRAIL-induced cell death could be its ability to stimulate the expression of TRAIL receptor(s).
