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The use of positive controls during immunohistochemical procedures rules out the hypothesis of false-negative reactions.
They did not differ from the others with regard to their protein contents, thus refuting the hypothesis of false-negative or false-positive cases associated with a low or high protein level [ 37].
The use of external or internal positive controls (positive breast cancer for HER-2, positive mastocytes in the cancer stromal reaction for CD117) during immunohistochemical procedures rules out the hypothesis of false-negative reactions.
Our results confirm the good concordance between IHC and FISH analyses in ovarian cancers because all the samples showing 1+ staining or cytoplasmic staining were not amplified, thus excluding the hypothesis of possible false negatives.
Under the H0 hypothesis, the probability of false alarms is given by (8).
Under the H0 hypothesis, the probability of false alarms for the pair of sensor nodes 1 and 2, is given by (24).
Given that two out of six tests support the true hypothesis, the frequency of false positives among the positive findings is given by: 2/3 α / (1/3 (1−β)+2/3 α)≈0.26, and stays constant over the rounds.
As a function of the involved parameters, our study evaluated the test statistics under both the null and alternative hypotheses by estimation of false positives (including significant test results caused merely by changes in blood glucose) and the power to detect true differences in the tumor glucose uptake rate limit.
Multiple independent testing increases the fraction of false hypotheses among those hypotheses that are supported by at least one positive result.
The paper is his "On the Function of False Hypothesis in Ethics," published in 1916.
All randomizations were done for a rejection of the null hypothesis and a control of false alarm rate at p = 0.05.
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