Hypothesis testing necessitates an intellectually rigorous, null hypothesis approach that is distinct from a high throughput fishing expedition in search of a hypothesis.
This alternative phylogenetic hypothesis, if true, would necessitate reinterpretation of morphological characters shared by anthozoans as symplesiomorphies (retained from the common ancestor) rather than synapomorphies.
In the absence of more specific markers, we propose that the effective translation of the CSC hypothesis into patient benefit will necessitate the use of a panel of markers to robustly identify tumours enriched for CSCs.
Nevertheless, the dearth of published research in pediatric TTM necessitates efforts at empirical hypothesis generation wherever possible, which is what led to the exploration reported above.
And when things don't work out, it doesn't always necessitate abandoning your original hypothesis.
This discovery necessitates a significant revision of hypotheses concerning the origins and early radiation of Neosauropoda.
If this hypothesis is true, however, it would once again necessitate secondary simplification and loss of neural Xlox expression in some lineages such as Capitella [ 7].
Imperfection of packing necessitates exploring some additional assumption called a closing hypothesis.
If the appearance of M+1 does not necessitate the disappearance of M (which by our hypothesis possesses the power to bring about M+1), M would then continue to generate precisely M+1 repeatedly forever.
Specifically, this research directly supports the hypothesis that tightly controlled relative and absolute polyketide stereochemistry may not necessitate the action of exquisitely stereoselective domains but, instead, be the consequence of iterative, stereospecific checkpoints or gatekeeper domains.
