The rapid rise of allergic disorders in developed countries has been attributed to the hygiene hypothesis, implicating that increased environmental sanitation in early childhood may be associated with higher incidence of hypersensitivity.
The amyloid cascade hypothesis implicates Aβ as having a crucial role in the pathogenesis of AD [6] and as a result is an important therapeutic target.
The metals hypothesis implicates redox-active copper ions in the pathogenesis of AD and the Cu2+ coordination of various Aβ peptides has been widely studied.
Recent data support this hypothesis, implicating UCH L1 in the up-regulation of metastasis in non-small cell lung cancer [20], and in the proliferation and invasive capacity of malignant B-cells [21].
We test a hypothesis implicating CaMKII in the arrhythmogenesis accompanying metabolic acidification.
These findings further support the hypothesis implicating pool chlorine in the rise of childhood asthma in industrialized countries.
An alternative hypothesis implicates EBV infection as an agent important in the pathogenesis of LIP in HIV uninfected persons [ 8].
The hypothesis implicating the multifactorial nature of the BEN aetiology assumes that genetic factors create a predisposition to BEN [ 76].
A second proposed hypothesis implicates CNIs in a disturbance of the vascular supply to bones, with changes in perfusion and permeability leading to marrow edema [ 8, 27].
This excludes all riboswitches found to be mutually conserved in all compared chromosomes, strengthening a hypothesis implicating cis acting RNA regulation as an ancient mechanism [ 36].
