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Though the findings are highly intriguing in light of the critical window hypothesis, caution must be exercised when interpreting observational studies due to their inherent limitations.
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First, however, more rigorous studies are needed to confirm the hypothesis, cautions oncologist Michael Kelley of the National Cancer Institute in Bethesda, Maryland.
Nonetheless, accepting the null hypothesis requires caution.
Although restating the biological hypothesis, he cautioned that other explanations for the hydrogen and acetylene findings are more likely: the possibilities of yet unidentified physical or chemical processes (e.g. a surface catalyst accepting hydrocarbons or hydrogen), or flaws in the current models of material flow.
Because our study is the first to directly contrast the Rhineland and Khazarian hypotheses, a caution is warranted in interpreting some of our results due to small sample sizes and availability of surrogate populations.
If this seemed to solidify the Columbus hypothesis, the researchers cautioned that a "transfer agent between humans and nonhuman primates cannot be ruled out using the available genetic data".
The stronger effect size for intrapartum compared to intrauterine transmission is interesting, possibly useful for developing mechanistic hypotheses, but warrants caution with interpretation due to sample size.
I don't dismiss the hypothesis but I also caution people that a lot of highly contaminated regions of the world today aren't seeing the problems with their girls that we're seeing with ours".
"Once again, these are hypotheses," Dr. Domatob cautioned.
Therefore, the null hypothesis should be accepted with caution.
In the meantime, we modestly think that the "null hypothesis" should be considered with caution.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com