Sentence examples for hypothesis binding from inspiring English sources

In support of this hypothesis, binding affinity to CRF1 of the chimeric peptides [Pro11Ile12Gly13]h/rCRF, [Pro11Thr12Asn13]h/rCRF, and the corresponding rUcnI analogs was found to be decreased by three orders of magnitude, whereas binding affinity to CRF2 was much less affected.

According to this hypothesis, binding should depend not on the local structure, but rather on an interaction pathway on the protein that takes part in the collective reorganization of the residues to accommodate for the best and most favorable conformation of the protein-ligand complex.

To test that hypothesis, binding of probes 3 and 9 was footprinted in solution separately with NMIA and kethoxal.

According to their hypothesis, binding of NO to GSH results in a radical intermediate GSNOH, which will be oxidized to GSNO in the presence of suitable oxidizing agents (Eqs. (7) and (8), in which A represents an electron acceptor).

The kinetics of ibuprofen and mefenamate inhibition of 2-AG oxygenation are typical of noncompetitive inhibition, consistent with the hypothesis that binding of the inhibitor at one subunit inhibits productive binding of 2-AG at the other subunit.

The first test further assumes in the null hypothesis that binding locations of a given TF falls uniformly among the set of positions containing binding locations for any TF.

In this hypothesis, JMD binding of p120-catenin, or other proteins, to P-cadherin must differ from the binding to E-cadherin or N-cadherin in terms of strength, conformation, or recruitment of other members of the complex.

Conversely, the second test modifies this by assuming in the null hypothesis that binding locations of the given TF falls inside gene regions of the given disease proportionally to how often the binding locations of this TF on average falls inside gene region sets across all diseases.

According to this hypothesis, ATP binding to myosin causes dissociation of the head domain from F-actin.

In order test our hypothesis that binding of HBP to endothelial proteoglycans is required for the increased permeability, Heparinase III or Chondroitinase ABC were used to selectively cleave either heparan sulfate or chondroitin sulfate/dermatan sulfate, respectively, from the endothelial surface [3, 22 24].

In order to test the hypothesis that binding at this site blocks 3Dpol polymerase activity, we generated the K59A and K177A mutants of 3Dpol and tested their susceptibility to three inhibitors (5D9, 1A8, and 8C5).