Note that, although this finding is consistent with our hypothesis as a proof of principle, the specific different CGPs that may have the most potent effect in fusion between HAb2 cells or other cells remain to be identified.
Our proof-of-principle study strengthens the hypothesis that neoplastic diseases generate characteristic miRNA fingerprints in blood cells.
Then, the likelihood ratio statistics for checking the hypothesis of equal scaling parameters of principle components of p-power exponentially distributed two-dimensional vectors are considered both under independence and under rotational or correlation type dependence.
We selected a «three-stage» design for our experiment, which should be viewed as hypothesis-generating, rather than proof of principle.
The proof of principle for our hypothesis that refined HDL phenotyping would provide increased sensitivity in detecting loci affecting HDL metabolism compared with HDL-C is illustrated by the findings for PLTP and LIPC.
Proof of principle for this hypothesis is based on neonatal laboratory rodents exposed to experimental diethylstilbestrol (DES).
Further proof of principle of our hypothesis was the greater magnitude of risk among people exposed to immunosuppressive drugs (systemic glucocorticoids), as expected on the basis of data from other groups of immunosuppressed patients, albeit with limited statistical precision.
As proof of principle of this hypothesis, Cuzick and colleagues [ 127] demonstrated in the IBIS-I prevention trial that women who had a more than 10% reduction in density with tamoxifen had a 70% reduction in risk of breast cancer risk but that for women with less or no reduction in density there was no reduction in risk.
The power/sample size calculation method proposed by Vong et al. is based on the hypothesis testing principle of the LRT in nonlinear mixed-effect models.
Invoking conditions (hbox {F5}^), or F5 and convexity of B in p, we then have from the classical maximum principle, under the hypotheses of Theorem 1.1, begin{aligned} sup _{Omega }u_{tau tau }le sup _{partial Omega }|u_{tau tau }| + C, end{aligned} (2.10 which implies a global upper bound for (D^2u), since (tau ) can be any unit vector.
