► Hypothesis for development of Alzheimers disease.
Most hypotheses for the development and maintenance of work-related muscle pain propose that muscle-cell activity produces energy demands that are not met by circulation, thereby resulting in hypoxia, energy crisis, and accumulation of metabolites in the muscle [ 6].
Hypotheses for the development of smooth muscle atrophy include vasculopathy with resultant denervation, production of autoantibodies targeting smooth muscle and/or entrapment and destruction of smooth muscle by fibrosis [ 2].
A reasonable hypothesis for the development and growth of HELUs is increased proliferation due to large increases in ER-α and PR, which are the receptors for these mitogens.
Determining the relative contributions of genomic imprinting, karyotype and mosaicism to variation in Turner syndrome phenotypes has important implications for both clinical treatment of individuals with this syndrome, and hypotheses for the evolution and development of human sexual dimorphism.
One hypothesis for the development of the aspherical femoral head is abnormal growth and lateral extension of the femoral head physis, with eccentric closure [21].
One hypothesis for the development of sensory profiles is that distinct pathophysiological mechanisms of pain generation produce specific sensory abnormalities.
We used terrain analysis and with cosmogenic nuclide measurements of erosion rates to quantitatively explore Wahrhaftig's decades-old hypothesis for the development of "stepped topography" by differential weathering of bare and soil-mantled granite.
These associations are compatible with the immune hypothesis for the development of mood disorders in at least a subgroup of mood disorder patients.
Based on the theoretical "two-hit hypothesis" for the development of transfusion-related ALI wherein neutrophils are initially primed by a risk factor (i.e., sepsis) and then activated by components of transfused blood [14, 30], patients with sepsis who are exposed to RBCs may be a population at increased risk for ALI after transfusion with blood of a long storage duration.
