The role of leaders is to quiz teams about their hypotheses and challenge their logic if those hypotheses appear to lack support.
First, developers of therapeutics should assume a leadership role in articulating hypotheses and challenging independent preclinical investigators to design and conduct rigorous randomized studies addressing the hypotheses in animal models that, as faithfully as possible, reproduce the clinical condition of interest.
While inductive qualitative studies are extremely useful to provide an understanding of the experience of care and social support in multigenerational households, robust instrumentation is required so that positivistic and deductive approaches can also be adopted to test hypotheses and challenge existing theoretical perspectives.
However, impairment of endocytic recycling argues against this hypothesis and challenges the IAV assembly model proposed.
Another study found that the transcription pre-initiation complex was pre-assembled on promoters of all erythrocytic-expressed genes, independent of any histone acetylation [ 44], supporting this hypothesis, and challenging the model that chromatin acetylation precedes transcription initiation in Plasmodium.
We briefly outline existing direct and indirect evidence for and against these hypotheses and the challenges to proving infectious causality, even in leukemia clusters.
Different SNPs will have different applicable hypotheses and the challenge is to identify the correct one to apply.
Therefore, we hope that this special issue will be of interest to a wide audience in basic and applied biomedical areas, especially those that embrace with excitement the search for new hypothesis and approaching challenges regarding NAFLD pathophysiology in the context of the MetSyn.
The current study, attempts to replicate the findings of the original study, and challenges hypotheses presenting a "one size fits all" model of HEV.
Hundleby (1997), a standpoint theorist, criticizes feminist empiricism for overlooking the vital role of feminist political activity, in particular, the development of oppositional consciousness, as a superior source of hypotheses and evidence for challenging sexist and androcentric theories.
