Exact(5)
In remnant kidney rats, vitamin D administration significantly reduced glomerular hypertrophy over placebo [ 89].
Second, the telmisartan-induced decrease in left ventricular hypertrophy over placebo in TRANSCEND did not translate into decrease in heart failure, and the telmisartan-induced greater decrease in left ventricular hypertrophy over ramipril in ONTARGET did not affect outcome.
A post hoc analysis of the Losartan Intervention for Endpoint Reduction (LIFE) trial reported that improvements in electrocardiographically determined left ventricular hypertrophy over time were associated with lowered diabetes incidence (1, 2).
By contrast, Ang-(1 7) infusion was associated with adverse cardiovascular effects in STNx rats and significant increases in blood pressure and left ventricular hypertrophy over and above that in STNx rats treated with vehicle.
Their results revealed inheritance of epigenetic cardiac hypertrophy over at least three generations, and efficient hereditary transmission was correlated with the presence of miR-1 in the sperm nucleus.
Similar(55)
Insulin-like growth factor-I (IGF-I) plays a crucial role in muscle regeneration, can reduce age-related loss of muscle function, and cause muscle hypertrophy when over-expressed [ 1- 5].
The idea that a mutation(s) leading to vacuolar hypertrophy and over-expression of vacuolar calcium pumps constitutes a means for depriving the cytosol of calcium by excessive vacuolar storage, enabling manipulation of intracellular calcium, is one of possibly widespread utility.
Furthermore, stimulation of isolated cardiomyocytes by phenylephrine induced hypertrophy, and PDE5A over-expression amplified natriuretic peptide gene expression from phenylephrine stimulation [62].
The function of PEG11 in normal fetal skeletal muscle is unclear as is its precise role, if any, in generating muscle hypertrophy when it is over-expressed in callipyge skeletal muscle.
During the progression of cardiac hypertrophy to failure over a 31 days period there was a dramatic decrease by 50% of the MLP transcripts level.
Indeed, deletion of miR-1 altered regulation of cardiogenesis, electrical conduction and cell cycle of cardiomyocites, and miR-133 plus miR-1 regulate cardiac hypertrophy, as their over expression inhibits it.
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