During the 15-minute hypoxic insult, body temperature was elevated to 40°C in 16 animals (hyperthermic hypoxic insult group), and was maintained at 37°C in 16 animals (normothermic hypoxic insult group).
One day after hyperthermic seizures or hyperthermia, animals demonstrated enhanced latency to the PTZ-induced myoclonic (88%and53%3%, respectively), clonic (60% and 60%, respectively) and tonic seizures (233% and 659%, respectively).
Acute and chronic hyperthermic treatments in diabetic animal models repeatedly improve insulin sensitivity and glycemic control.
At the earliest time point examined (14 weeks post-inoculation with ME7, 4 h after poly I C), poly I C induced the predicted mild hyperthermic response in normal (NBH) animals but caused hypothermia in prion-diseased (ME7) animals.
This hypothesis is supported by animal studies demonstrating increased hyperthermic response to MDMA in warm crowded environments [ 27].
The animal was weak, dyspneic and hyperthermic, and a clinical examination indicated the presence of gas and edema in the limb.
This compromises both oxygenation and thermoregulation, and although it is impossible to measure rectal temperature, heart rate and arterial oxygen saturation from the very moment the animal is lying down it is quite clear from our measurements that the animals initially were both hypoxic and hyperthermic.
Furthermore, the restraint of the animal may be stressful and compromise the well-being, leading to a hyperthermic response, although usually of short duration only [ 4].
In 2011, a zookeeper resigned after failing to follow animal-handling instructions that resulted in the death of a corn snake from hyperthermic shock.
Recent experimental data in different animal models of cardiac arrest, stroke and myocardial infarction suggest that warm reperfusion under normal or hyperthermic conditions could increase the deleterious effects of the reperfusion.
Eleven animals were given saline in a 39° to 40°C environment (EIH group, 10 rats survived) and had a hyperthermic profile very similar to the rats given AMPH.
