Exact(2)
Phase-contrast MR-derived mean average velocity <11.7 cm/s can help in detection of pulmonary hypertension (sensitivity 92.9 % and specificity 82.4 %) [7].
We used validated algorithms from hospital (CIHI-DAD) and outpatient fee claims (OHIP database) to identify pre-pregnancy diabetes (sensitivity 0.86, specificity 0.97) 15 and chronic hypertension (sensitivity 0.72, specificity 0.95).
Similar(58)
The validation studies of the MDC and ISC found both datasets suffer from under-reporting of hypertension (sensitivities 50 86%) but that specificities were very high (99.1 99.8%)[ 22, 23].
The opposite was observed for hypertension (good sensitivity of drug screening).
An association of JAM-A with hypertension and sensitivity to blockers of ANG II signalling were also evident in humans.
Exenatide and GLP-1 improved hypertension, insulin sensitivity, vasodilatation, and renal diuresis in animal studies [ 13, 17- 20].
Susceptibility is variable between individuals depending on endo- and exogenous risk factors, such as essential hypertension, salt sensitivity, old age, malnutrition, use of diuretics, chronic inflammatory conditions and mutations in the 11-beta-HDS2 gene.
To assess the potential effects of 'regression to the mean' phenomenon on the prevalence of hypertension, a sensitivity analysis was conducted among participants with a raised initial BP (SBP/DBP≥140/80 mm Hg) and who had their BP taken a second time on the same day.
31, 35 The hypertensive effect mediated by the α2B-AR has been shown to be especially important in individuals with salt-sensitive hypertension because salt sensitivity is associated with a positive family history of primary hypertension, and is also a characteristic in a large proportion of patients with primary hypertension.
In usual risk women, 24-hour systolic blood pressure of ≥115 mm Hg and sleeping systolic blood pressure of ≥106 mm Hg were predictive of later preeclampsia or gestational hypertension, but sensitivities were low (77% and 54%, respectively).
Hypertension and salt sensitivity are complex phenotypes whose pathophysiology remains poorly understood and, remarkably, salt sensitivity is still laborious to diagnose.
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