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CKD exacerbates hypertension, limits medication choices in patients with diabetes, and contributes to a range of metabolic abnormalities and complications such as anemia, acidosis, hyperphosphatemia, hypoalbuminemia, and hyperparathyroidism.
In terms of ACE/ARB prescription and blood pressure control, the overlap between management of CKD and management of both diabetes and hypertension limits our ability to distinguish any impact of CKD documentation from interventions affecting diabetes and hypertension management.
Similarly, the lack of ethnicity data about those with established hypertension limits the interpretation of our finding that the ethnicity of the local population was unrelated to success at blood pressure control, whereas others have noted that blood pressure control is poorer in hypertensive patients from an ethnic minority.
Similar(57)
While a diet rich in anti-oxidant has been favorably associated with coronary disease and hypertension, limited data have evaluated the influence of such diet on subclinical disease.
The developed model has no direct mechanistic link between exposure and appearance of hypertension, which limits extrapolation outside the range of dosing schedules studied.
Differences in study populations, including small numbers of participants in some studies and inconsistencies in the definition of hypertension outcomes limits confidence in conducting a thorough systematic review of available literature.
The largest limitation in interpreting nebivolol trial data comes from an absence of outcomes trials in patients with hypertension, which limits our ability to assess the effect of nebivolol treatment on cardiovascular morbidity and mortality with any precision.
[ 18] Clinicians are familiar with the concept of taking three blood pressure measurement readings to assess whether individuals are over a treatment threshold for hypertension; this limits measurement error due to the instrument's imprecision and within person variation.
The limitations of treatment, namely nephrotoxicity and hypertension, frequently limit use.
Current therapies for reducing raised intracranial pressure (ICP) in conditions such as idiopathic intracranial hypertension have limited efficacy and tolerability.
However, existing modes of delivery for the treatment of chronic pulmonary hypertension are limited due to the bulk and heft of large tanks of compressed gas.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com