During binge administration (3 times per day, 3 successive days), increased locomotor effects at day 3 (after the 9th injection) in comparison with day 1 (after the 1st injection) supported naphyrone-induced hyper-sensitization process.
Previously, we reported hyper-sensitization of osteoarthritic cells to FGF-2 compared to normal chondrocytes [ 18].
We therefore suggest that the combination of hyper-sensitization to GM-CSF in Nf1 −/− cells and activation of ERK by HQ could explain the increased proliferation of null cells relative to WT following HQ treatment.
It may relate to neural and vascular causes, involving cerebral cell hyper excitability, sensitization of the trigeminovascular pathway, correlative predisposing genes and environmental factors.
The presence of pressure pain hypersensitivity in distant pain-free areas indicates sensitization of the central nervous system in pianists suffering from neck pain; however, the absence of pressure hyper-sensitivity over the symptomatic areas makes this assumption inconclusive.
Some are hyper-sensitive.
In infected mice subjected to an experimental protocol inducing airway inflammation and hyper-responsiveness through sensitization and challenge with ovalbumin, the protection against asthma can be abrogated by Treg depletion [ 40].
This 'peripheral sensitization' induces a hyper-excitability of nociceptive neurons in the central nervous system ('central sensitization'), and the two together generate the features of pathophysiological nociceptive pain, namely allodynia and hyperalgesia [ 2, 8, 9].
There is preliminary evidence that central hyper-excitability or signs of central sensitization predict recovery [ 3].
Challenging serum starved cancer cells with CDDP triggers the hyper-activation of ATM/Chk2/p53 signaling resulting in sensitization of cancer cells to CDDP.
Alterations in the physiology of sensory pathways, such as sensitization (reduced threshold for stimulation), hyper-excitability (amplification or prolongation of nerve discharge) or spontaneous nerve activity, can be associated with specific molecular changes.
