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The possible mechanism was that the pathogen injury of the airway epithelial, which caused the airway to become hyper responsive and induced asthma to occur more easily.
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To mount a defense against pathogens or respond to other damaging or noxious stimuli, the hosts' innate immune systems need to achieve allostases; in other words, maintain sufficient innate response yet not become hyper-responsive or desensitized to microbial recognition.
As NOD-derived B lymphocytes are hyper-responsive to LPS in terms of CD80 (B7.1) expression [35], we demonstrated that this response is attenuated by cSN50.
They have found that when you repeatedly take a substance like cocaine, your dopamine system becomes hyper-responsive, making the drug extremely difficult for the addicted brain to ignore.
Hyper-responsive systems produce allergies.
During ketamine recovery, animals are hyper-responsive and ataxic.
Recent developments suggest a pathophysiological model of PTSD which includes hyporesponsive prefrontal cortical regions and/or a hyper-responsive amygdala.
Morphine pretreated rats, furthermore, show a switch in β-endorphin-induced locomotor activity from being hyper-responsive to hypo-responsive when going through withdrawl (Schwartz et al. 1982).
This may be due to normally innocuous meningeal nociceptors becoming hyper-responsive to rhythmic fluctuation in intracranial pressure that is produced by normal arterial pulsations [31, 32].
Yoshida et al. (2002) found that hys1 seedlings with exogenously applied sugars were hyper-responsive to glucose, implying that sugar may play a role in the early induction of senescence.
"The neural circuit implicated in reward-and-risk-related processes has been found to be hyper-responsive in socially anxious adolescents".
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