Sentence examples similar to hyper profile from inspiring English sources

Although the latter analysis implicates the possibility that binding of sub-groups of transcription factors are variably affected by DNA methylation pattern, and differences between hearts and sperm may exist for specific sets of TF, the aggregate hyper-methylation profile in the former analysis suggests that conserved consensus TF motifs are mainly hyper-methylated.

Indeed, Mrs. Clinton is guarded by nature, friends say, a fundamentally "private person" despite her hyper-public profile.

Experiments conducted in immunocompetent mice revealed that the hyper-attenuated profile observed with MTBVAC erp− strain did not compromise its protective efficacy profile in comparison with BCG.

Consistent with the present results, stimulation of Gαi2-deficient peripheral T cells induced a hyper-responsive profile of interleukin-2, tumor necrosis factor, and interferon-gamma production [18].

This hyper-methylation profile again suggests that where conserved consensus motifs for TF binding exist outside of CGI, promiscuous or disorderly TF binding may be controlled by DNA hyper-methylation.

Similarly, although empirical TFBS containing the expected conserved consensus motif in CGI ("set 4") were hypo-methylated, non-CGI of this dataset showed a hyper-methylation profile in sperm and a neutral methylation profile in hearts.

Most importantly, we found that while conserved consensus motifs without biologically proven TF binding have a hyper-methylated profile, sites of biologically proven TFBS have the opposite hypo-methylation profile.

At the locations of predicted TFBS for this subset of 17 TF N == 771,221, we called "set 3", Figure 1), a hyper-methylation profile was again found in both hearts and sperm.

In contrast to the aggregate hyper-methylation profile at all predicted TFBS ("set 1", Figures 2A and 2B) and at the subset of 17 TFBS ("set 3", Figures 3A and 3B), predicted TFBS that were biologically proven TFBS ("set 4") showed an aggregate profile of hypo-methylation in both hearts and sperm.

When examined in further detail for each individual TF, the large majority of TF showed a hyper-methylation profile in both hearts and sperm (Table 1) but a smaller proportion showed a variation of hypo-methylation pattern in both tissues, an opposite pattern in either, or a neutral methylation pattern.

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